New Technique I played around with...

[klam]

Your straight out of camera image doesn't have much skin texture to begin with so very little smoothing is needed if any at all. I would focus more on removing blemishes, acne, etc. Perform a slight skin smooth if needed, then do a local sharpen as the last step. Sharpening the eyes, lips, whatever is in focus. Sharpening the eyes might require different settings than sharpening the lips or hair would.

global sharpening should always be the last step done in my opinion. I use different sharpening settings for web, resolution size, print, etc. Sharpening an image for web might look good on a monitor but it might look under sharpened when printed.

[sk66]

Originally Posted by Rentham

For people I go with an Amount of around 65 and a Radius of .06. I don't push the Detail slider much past 30. Keep in mind this stuff is for capture sharpening.

Radius @1, detail @25, sharpening at 50%...That's my starting point and seldom move to far from there...subject dependent I will often end up @ 100% sharpening with the masking near 100%

Originally Posted by Rentham

And frankly I have no idea why you'd need any Noise Reduction on an ISO 400 image taken with a modern camera, let alone the ungodly amount you have here.

I usually have *some* luminance reduction and occasionally some color noise reduction, but never above 50% and the detail slider stays low (25% or less).

By putting the detail sliders so high you are negating the other settings in noise reduction and causing excessive sharpening artifacts.

[sk66]

A nice trick is to hold down the alt key while moving the sharpening sliders to better see what you are doing.

This was the best I could do with just basic LR settings.
A big part of the issue is it's not terribly sharp to start with and trying to make it tack sharp @ 100% in LR is never going to work....It won't even work in PS but could probably do a little better.