I always shoot in full manual. If I'm indoors without a flash I'll generally be at 400 or 800 on my K10D. There is very little noticeable grain below 1600, and even 1600 is fully useable (and barely indistinguishable from lower ISOs once I run it through NoiseNinja).
Outdoors in good light I will of course shoot at ISO 100.
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Digital: Canon 1DMkii, EF 17-40mm f/4 L, EF 50mm f/1.4, EF 85mm f/1.8
Film: Pentax LX, Pentax FA 50mm f/1.4, Pentax A 70-210 f/4, Pentax A 28mm f/2.8, Vivitar 2x Teleconverter, Vivitar 285HV
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