In closest Subject mode spot metering is on the focus area. In all other modes the spot metering occurs in the center regardless of the focus zone the camera (or you) select. If you know the area you wish to meter is not within the focus zone for closest or in the center for all other focus modes, then meter using the spot meter zone and use your AF/AE lock. If you do not want the focus locked along with the exposure you can reprogram that button to only do AE lock.
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