Noise Ninja doe a good job, but be careful not to overuse it! It is a real pixeldestroyer.
As for the ISO question: there are three things that you can use to get the light right: aperture, shutter speed and ISO. I have learned that you should use aperture and shutter speed to get it right and only raise the ISO value if there is too little light to handle with aperture and shutter speed.
And then again..you can use a very high ISO value for creative reasons..
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