Remember that your aperture will also affect your focus as it will affect your depth of field. The smaller the aperture (larger the number), the greater the depth of field. If you use a wide aperture, less of your picture will be in focus as it moves away from the point you chose to focus on. Of course at the smaller end (above about f/13 or so), you will start to experience a loss of sharpness due to diffraction, which will get worse as the aperture gets smaller. The point at which this loss of quality begins as well as how bad it will get depends on your lens. Every lens is a bit different.
It's all a matter of the choice you must make for each individual photograph.
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Cameras: Pentax K5, K20D, K10D, *istDL, ZX-7, ZX-L
Eagle Vista Photography - Flickr - Pentax Gallery
"Anybody can make the simple complicated. Creativity is making the complicated simple." Charlie Mingus
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