I tend to stick with autofocus when possible....I generally find the camera does a better job of focusing than I do.
I find that when working with shallow DOF I tend to manually focus a little "too deep". I've learned to manually focus "slightly short" to take advantage of the 1/3- 2/3 DOF effect in order to compensate. I don't know if my problem is due to wearing glasses or just my tendency (and this is true for most people) to want to "plus up" the focus (i.e. oversharpen).
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