I realized that you are right about the DPI, so I decided to do some more exact calculations. First, you won't have four 8x10's next to each other, due to overlap, but we'll work with something close.
So, let's assume you have a 6 MP D40, and your images overlap by 1,000,000 pixels. Then four images will have a total of (6+5+5+5) = 21 MP. This gives 220 DPI if you print at 12x36. So, you will have pretty awsome image quality still!
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