[RustySterling]

I like having zooms for the versatility but I also like primes for sharpness. So here is what I have and why:

Sigma 10-20mm f/4-5.6 widezoom (gives me some great wide angle choices on APS-C)
Canon 17-40mm f/4L zoom (good range for a walk around on APS-C)
Canon 24-105mm f/4L zoom IS (pushes the focal length out a bit more and very sharp glass)
Canon 35-350mm f/4-5.6L (a super-zoom that gives me lots of versatility)
Canon 100mm f/2.8 macro (great prime for macro and portraits and one of the best non-L lenses out there)
Canon 200mm f/2.8L (just a great prime for lots of reasons and great for sports -- sharp, sharp, sharp -- one of the sharpest L lenses available in it's range)

I'll likely get a Canon 400 f/4L in the long term and may even go for the Canon 70-200 f/4L or f/2.8L for a bit more zoom versality but with the 35-350 I'm not in a hurry on the 70-200 (even though I know that the glass will be much sharper than the 35-350). I also plan on getting the Canon 50mm 1.8 or 1.4, since this is one of the most versatile lens around.

Frankly, the biggest factor I see hampering me is having only one body. I plan on getting another body in the future (hopefully near future but not too sure right now) and would lean toward a full-frame over an APS-C body to get fuller advantage of some of the lenses I have. However, I went for good glass first because of a lot of advice on this website.

Like others have said, each of us has different needs. I'm a former reporter/photojournalist (worked as a double-threat man in newspapers for 15 years) and made my lens choices based on that experience. They are choices that others might not make but it works for me.