[pilothaz]

This is a good question, I would like to hear other people's ideas on this but I will throw my two cents in.

One of the main things is to get the subject comfortable around you while you are working. When they are in this state they won't feel awkward around you and be embarrassed about how they are 'weird'. Asking general questions and finding out a general commonality between the people is a great start.

What it basically comes down to is breaking the tension in the room and just being able to have fun while you are working and make it enjoyable for them.

Hope that helps.