I switch back and forth between my Sigma 18-200 OS and my 50mm f1.8. The Sigma has great overall optics and is very versatile with the stabilization and focal length options. The 50mm is super sharp and works great in low light.
I've been trying my Sigma 28-80mm Macro a bit more lately since it's a bit more lightweight (pretty impressed with the optics so far), but I just keep coming back to the 18-200.
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Canon EOS 40D; Canon EOS 400D/XTi; Canon EF-S 17-55mm f/2.8 IS USM; Sigma 18-200mm f3.5 O.S.; Canon 50mm f1.8; Canon 18-55mm f3.5; Sigma 28-80mm f3.5 Macro; Digipower Battery Grip; Canon 430EX Flash; Canon EOS Rebel G 35mm Film Photoblog: http://blog.manningthecamera.com; Flickr: http://flickr.com/photos/psykon99/
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