Not my greatest work, just a quick effort. In no particular order I...
Removed wrinkles and smoothed skin using the healing brush, whitened smile using dodge, brightened eyes using an adjustment layer, darkened lipstick using the burn tool, made a mess of the background (hence the crop), thined the neck a tiny bit using the smudge tool, and lightened the hair color slightly with dodge.
I could have done a better job with a higher res version I think.