I bought an Epson Perfection V500 Photo recently, and I'm very happy with it. For best results, I use it in "professional" mode which is time consuming but worth it for small batches. For larger batches I would use some of the dummy modes in low(er) resolution to get them all on the computer. Then go back and re-scan the favorites at a high resolution. If you really have hundreds of old pics then you'll drive yourself crazy trying to scan them all at high res the first time. Just my 2 cents . . .
And it works great for 35mm and 120 medium format, although I don't know if the high res center lens area meant for negatives would be large enough for 4X5. Probably so, but you'd have to check the specs.
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Nikon D80, 18-200, 105 macro VR, 18-55, 50 f/1.8; Tokina 11-16 f/2.8
SB600 x 2; Canon A570 IS; Bonica XP Neon Underwater Strobe
Film Cameras: Lomo LC-A+, Diana+, Canon AE-1
OK to edit and repost pics for DPS forums!
flickr; ihardlyknowher; My most interesting pics on flickriver
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