Good question... I spend a lot of time doing wildlife photography & landscapes so I do not use a flash very often for these purposes. When doing close-ups of flowers or small birds in trees, you can't avoid having to use a flash for clarity and reducing the use of high ISO for sharpness.
IMHO high ISO, no matter how good the camera, will produce graininess in dark areas and many background situations. This is not a desired effect for large prints or crops. Noise reduction software can help but you mess up other pixels in other places.
98% of my pictures are taken without flash but sometimes it's nice to have it standing by so I can use a lower ISO or brighten something up.
Allen...
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Gear: Canon 1DMkIII | Multiple Canon lenses
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